Th2-Mediated Murine Colitis Chronic Monoxide and Heme Oxygenase-1 in An Anti-Inflammatory Role for Carbon
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Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1–dependent pathway
Heme oxygenase (HO)-1 and its metabolic product carbon monoxide (CO) play regulatory roles in acute inflammatory states. In this study, we demonstrate that CO administration is effective as a therapeutic modality in mice with established chronic colitis. CO administration ameliorates chronic intestinal inflammation in a T helper (Th)1-mediated model of murine colitis, interleukin (IL)-10-defici...
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